Children’s National Research and Innovation Campus sits on a 12-acre portion of the former Walter Reed Campus. The project consists of rehabilitating five existing buildings – Buildings 3, 52, 53, 54 and 54X. Building 54 was constructed in the 1950s under the direction of President Eisenhower with the intent to withstand a 15 megaton nuclear blast and used as a medical research laboratory. New window openings were cut into the thick exterior concrete walls, existing columns were cut and transferred, and the floor was upgraded to meet vibration criteria for new lab equipment for Virginia Tech’s new research facility. Other buildings consisted of full-scale renovations and include a new outpatient care center, a new theater for medical presentations, and a new solar array installed on an existing parking garage. The rejuvenated campus is expected to provide accessible care for the community while advancing research for genetic medicine and rare diseases.